Manzanillo is a city and seat of Manzanillo Municipality, in the Mexican state of Colima. The city, located on the Pacific Ocean, contains Mexico's busiest port, responsible for handling Pacific cargo for the Mexico City area. It is the largest-producing municipality for the business sector and tourism in the small state of Colima.

Colima, officially the Free and Sovereign State of Colima, is among the 31 states that make up the 32 Federal Entities of Mexico. It shares its name with its capital and main city, Colima.