Manzanola is a Statutory Town in Otero County, Colorado, United States. The town population was 341 at the 2020 United States Census.

Otero County is a county located in the U.S. state of Colorado. As of the 2020 census, the population was 18,690. The county seat is La Junta. The county was named for Miguel Antonio Otero, one of the founders of the town of La Junta and a member of a prominent Hispanic family.