The Marañón River is the principal or mainstem source of the Amazon River, arising about 160 km to the northeast of Lima, Peru, and flowing northwest across plateaus 3,650 m high, it runs through a deeply eroded Andean valley, along the eastern base of the Cordillera of the Andes, as far as 5° 36′ southern latitude; from where it makes a great bend to the northeast, and cuts through the jungle Ande in its midcourse, until at the Pongo de Manseriche it flows into the flat Amazon basin. Although historically, the term "Marañón River" often was applied to the river all the way to the Atlantic Ocean, nowadays the Marañón River is generally thought to end at the confluence with the Ucayali River, after which most cartographers label the ensuing waterway the Amazon River.

The Amazon basin is the part of South America drained by the Amazon River and its tributaries. The Amazon drainage basin covers an area of about 7,000,000 km2 (2,700,000 sq mi), or about 35.5 percent of the South American continent. It is located in the countries of Bolivia, Brazil, Colombia, Ecuador, Guyana, Peru, Suriname, and Venezuela, as well as the territory of French Guiana.