Sir Marc Armand Ruffer CMG was a France-born British experimental pathologist and bacteriologist. He is considered a pioneer of modern paleopathology.

Paleopathology, also spelled palaeopathology, is the study of ancient diseases and injuries in organisms through the examination of fossils, mummified tissue, skeletal remains, and analysis of coprolites. Specific sources in the study of ancient human diseases may include early documents, illustrations from early books, painting and sculpture from the past. All these objects provide information on the evolution of diseases as well as how past civilizations treated conditions. Studies have historically focused on humans, although there is no evidence that humans are more prone to pathologies than any other animal.