Margaret Hardenbroeck de Vries Philipse was a prominent and wealthy merchant in the colonial Province of New York. She inherited great wealth from her first husband after his early death, and later married another merchant and landowner, Frederick Philipse, who became 1st Lord of Philipse Manor.

Frederick Philipse, first Lord of the Manor of Philipseborough and patriarch of the Philipse family, was a Dutch immigrant to North America of Bohemian heritage. A merchant, he arrived in America as early as 1653. In 1662, he married Margaret Hardenbrook de Vries, a wealthy and driven widow. Together, and variously in league with slavers, pirates, and other undesirables alongside the prominent and respectable, the couple amassed a fortune.