Lady Margaret Lee was an English courtier. She was a sister of the poet Thomas Wyatt and a friend of Queen Anne Boleyn, second wife of King Henry VIII of England. Historians have speculated that she may have been present during Boleyn's execution.

Sir Thomas Wyatt was a 16th-century English politician, ambassador, and lyric poet credited with introducing the sonnet to English literature. He was born at Allington Castle near Maidstone in Kent, though the family was originally from Yorkshire. His family adopted the Lancastrian side in the Wars of the Roses. His mother was Anne Skinner, and his father Henry, who had earlier been imprisoned and tortured by Richard III, had been a Privy Councillor of Henry VII and remained a trusted adviser when Henry VIII ascended the throne in 1509.