Margaret of Savoy was the last Habsburg Vicereine of Portugal from 1634 to 1640. In Portuguese she is known as Duquesa de Mântua, being by marriage the Duchess of Mantua and Montferrat. She was also regent of Montferrat during the minority of her daughter from 1612.

The Iberian Union is a historiographical term used to describe the dynastic union of the Monarchy of Spain, which in turn was itself a dynastic union of the crowns of Castile and Aragon, and the Kingdom of Portugal, and of their respective colonial empires, that existed between 1580 and 1640 and brought the entire Iberian Peninsula except Andorra, as well as Portuguese and Spanish overseas possessions, under the Spanish Habsburg monarchs Philip II, Philip III, and Philip IV. The union began after the Portuguese crisis of succession and the ensuing War of the Portuguese Succession, and lasted until the Portuguese Restoration War, during which the House of Braganza was established as Portugal's new ruling dynasty with the acclamation of John IV as the new King of Portugal.