Margherita Aldobrandini, was an Italian noblewoman member of the Aldobrandini family and by marriage Duchess consort of Parma and Piacenza during 1600–1622. She was also Regent of both Duchies during 1626–1628 on behalf of her minor son.

Ranuccio I Farnese reigned as Duke of Parma, Piacenza and Castro from 1592. A firm believer in absolute monarchy, Ranuccio, in 1594, centralised the administration of Parma and Piacenza, thus rescinding the nobles' hitherto vast prerogative.