Margherita Aldobrandini, was an Italian noblewoman member of the Aldobrandini family and by marriage Duchess consort of Parma and Piacenza during 1600–1622. She was also Regent of both Duchies during 1626–1628 on behalf of her minor son.

The House of Aldobrandini is an Italian noble family originally from Florence, where in the Middle Ages they held the most important municipal offices. Now the Aldobrandini are resident in Rome, with close ties to the Vatican.