Margherita Aldobrandini, was an Italian noblewoman member of the Aldobrandini family and by marriage Duchess consort of Parma and Piacenza during 1600–1622. She was also Regent of both Duchies during 1626–1628 on behalf of her minor son.

Odoardo Farnese, also known as Odoardo I Farnese to distinguish him from his grandson Odoardo II Farnese, was Duke of Parma, Piacenza and Castro from 1622 to 1646.