Margherita Gonzaga was Duchess of Lorraine from 1606 until 1624 by marriage to Henry II, Duke of Lorraine. She was an agent of Pro-French and anti Protestant policy in Lorraine, and is most known for her support of her daughter Nicole's right to the Duchy of Lorraine. She also claimed her right to Monferrato during the Mantuan war of succession.

Countess Christina of Salm (1575–1627), was a Duchess consort of Lorraine; married in 1597 to Francis II, Duke of Lorraine.