Maria Angelina Doukaina Palaiologina or Marija Angelina Nemanjić or Anna Maria Angelina Doukaina Palaiologina was a Byzantine Greek-Serbian aristocrat and the self-proclaimed basilissa of Epirus from 1384–85, succeeding the rule of her murdered husband Thomas Preljubović. Maria and her husband were a famed couple as patrons of the arts during Tomo's rule of Ioannina from 1366 to 1384. She is portrayed in the icons.

Thomas Preljubović was ruler of the Despotate of Epirus in Ioannina from 1367 to his death in 1384. Thomas was an unpopular ruler and is appraised very negatively by his contemporaries. On December 23, 1384 he was stabbed to death by his guards at dawn. The conspiracy of the faction which overthrew him involved his wife Maria Angelina who succeeded him.