Marie Caroline Brehm was an American prohibitionist, suffragist, and politician. The Head of the suffrage department for the Woman's Christian Temperance Union (WCTU), she was a key figure in the Prohibition Party and Presbyterian Church, active in both local and national politics, and an advocate of reform laws. Twice she was appointed by the President to represent the United States at the World's Anti-Alcoholic Congress in Europe. Additionally, she was the first woman to run for the Vice President of the United States after the 19th amendment granted women the right to vote.

The Prohibition Party is a political party in the United States known for its historic opposition to the sale or consumption of alcoholic beverages and as an integral part of the temperance movement. It is the oldest existing third party in the United States and the third-longest active party.