Mark Gregory Clayton is an American former professional football player who was a wide receiver in the National Football League, primarily with the Miami Dolphins. He played college football for the Louisville Cardinals and was selected in the eighth round of the 1983 NFL Draft. He played with the Dolphins until 1992, earning five Pro Bowl and three second-team All-Pro selections. He finished his career playing one season with the Green Bay Packers in 1993.

The Louisville Cardinals football team represents the University of Louisville in the sport of American football. The Cardinals compete in the Football Bowl Subdivision (FBS) of the National Collegiate Athletic Association (NCAA) and compete in the Atlantic Coast Conference.