Mark Twain: Words & Music is a double-CD produced by Grammy Award-winner Carl Jackson, a Bluegrass and Country music artist, as a benefit for the Mark Twain Boyhood Home & Museum, a non-profit foundation in Hannibal, Missouri. The project tells the life story of Mark Twain in spoken word and song and features many well-known artists. "Run Mississippi" by Rhonda Vincent reached #2 on the Bluegrass Today charts the same week that "Comet Ride" by Ricky Skaggs reached #7. The album was released on September 21, 2011 and is the most downloaded Americana album of all time on AirPlay Direct, an online music source for radio stations, with more than 7,000 downloads its first year.

The Mark Twain Boyhood Home & Museum is located on 206-208 Hill Street, Hannibal, Missouri, on the west bank of the Mississippi River in the United States. It was the home of Samuel Langhorne Clemens, better known as author Mark Twain, from 1844 to 1853. Clemens found the inspiration for many of his stories, including the white picket fence, while living here. It has been open to the public as a museum since 1912, and was designated a National Historic Landmark on December 29, 1962. It is located in the Mark Twain Historic District.