Markina-Xemein is a town and municipality located in the province of Biscay, Bizkaia, in the Basque Autonomous Community, also known as the Basque Country, located in northern Spain. The origin of the town's name lies in its geographic location. The last town in the province of Bizkaia, Markina-Xemein lies between Gipuzkoa and Bizkaia. Coming from the Spanish word "marca" meaning "mark", Markina-Xemein marks the location where the Gipuzkoanos often battled the Bizkainos.

Biscay is a province of Spain and a historical territory of the Basque Country, heir of the ancient Lordship of Biscay, lying on the south shore of the eponymous bay. The capital and largest city is Bilbao.