Marksville is a small city in and the parish seat of Avoyelles Parish, Louisiana, United States. The population was 5,702 at the 2010 census, an increase of 165 over the 2000 tabulation of 5,537.

Avoyelles is a parish located in central eastern Louisiana on the Red River where it effectively becomes the Atchafalaya River and meets the Mississippi River. As of the 2020 census, the population was 39,693. The parish seat is Marksville. The parish was created in 1807, with the name deriving from the French name for the historic Avoyel people, one of the local Indian tribes at the time of European encounter.