Martha Connors is a fictional character appearing in American comic books published by Marvel Comics. She is usually depicted as a supporting character of Spider-Man, and the wife of Dr. Curt Connors, also known as the Lizard. Much of her character's story revolves around her constant suffering, yet perseverance through her husband's constant transformations. Martha was later injected with Curt's Lizard Formula to cure her of a deadly virus, which also mutated her into an anthropomorphic lizard.

The Lizard is a character appearing in American comic books published by Marvel Comics. Created by Stan Lee and Steve Ditko, he first appeared in The Amazing Spider-Man #6 as an enemy of the superhero Spider-Man. While the character has retained this role throughout most of his subsequent appearances, he has also been portrayed as a tragic antihero and occasional ally of Spider-Man. Connors is sometimes an ally of Spider-Man just as himself, and not necessarily as his alter ego.