Karl Marx's theory of alienation describes the estrangement of people from aspects of their human nature as a consequence of the division of labor and living in a society of stratified social classes. The alienation from the self is a consequence of being a mechanistic part of a social class, the condition of which estranges a person from their humanity.

The division of labour is the separation of the tasks in any economic system or organization so that participants may specialize (specialisation). Individuals, organizations, and nations are endowed with or acquire specialized capabilities, and either form combinations or trade to take advantage of the capabilities of others in addition to their own. Specialized capabilities may include equipment or natural resources as well as skills. Training and combinations of equipment and other assets acting together are often important. For example, an individual may specialize by acquiring tools and the skills to use them effectively just as an organization may specialize by acquiring specialized equipment and hiring or training skilled operators. The division of labour is the motive for trade and the source of economic interdependence.