Mary D. Kane is an American attorney from Maryland who was the Republican candidate for Lieutenant Governor in 2010, as the running mate of Bob Ehrlich. In October 2011, Kane became the President and CEO of Sister Cities International. Sister Cities International is a nonprofit organization for individual sister cities, counties, and states across the United States. Kane also sits on the board of Suburban Hospital, a member of Johns Hopkins Medicine and Mount St. Mary's University.

The 2010 Maryland gubernatorial election was held on November 2, 2010. The date included the election of the governor, lieutenant governor, and all members of the Maryland General Assembly. Incumbent Democratic governor Martin O'Malley and lieutenant governor Anthony Brown won re-election to a second term in office, defeating Republican former governor Bob Ehrlich and his running mate Mary Kane.