Mary Wriothesley, Countess of Southampton, previously Mary Browne, became the wife of Henry Wriothesley, 2nd Earl of Southampton, at the age of thirteen and the mother of Henry Wriothesley, 3rd Earl of Southampton. Widowed in 1581, she was Dowager Countess of Southampton until 1595, when for a few months until his death she was married to the courtier Sir Thomas Heneage. In 1598 she married lastly Sir William Hervey.

Henry Wriothesley, 2nd Earl of Southampton, was an English peer.