Maryland Route 180 is a state highway in the U.S. state of Maryland. Known for most of its length as Jefferson Pike, the state highway runs 14.95 miles (24.06 km) from U.S. Route 340 in Knoxville east to Ballenger Creek Pike and Interstate 70 (I-70) in Frederick. MD 180 is the old alignment of US 340 through Knoxville, Petersville, and Jefferson in the Middletown Valley of western Frederick County. The state highway was originally constructed in the early 1910s and designated US 340 in 1927. MD 180 was assigned to the highway bypassed by the US 340 freeway between Sandy Hook in far southern Washington County and Jefferson in the mid-1960s. The state highway was extended east to Frederick and south along Ballenger Creek Pike after the US 340 freeway was completed in the late 1960s. MD 180 was rolled back to Frederick and removed from Washington County in 1989.

U.S. Route 15 (US 15) is a part of the United States Numbered Highway System that runs from Walterboro, South Carolina, north to Painted Post, New York. In Maryland, the highway runs 37.85 miles (60.91 km) from the Virginia state line at the Potomac River in Point of Rocks north to the Pennsylvania state line near Emmitsburg. Known for most of its length as Catoctin Mountain Highway, US 15 is the primary north–south highway of Frederick County. The highway connects the county seat of Frederick with Point of Rocks, Leesburg, Virginia, and Charles Town, West Virginia, to the south and with Thurmont, Emmitsburg, and Gettysburg, Pennsylvania, to the north. US 15 is an expressway throughout the state except for the portion south of MD 28. The highway is a freeway along its concurrency with US 340 and through Frederick, where the highway meets US 40 and Interstate 70 (I-70). US 15 has a business route through Emmitsburg.