Maryland Route 2 is the longest state highway in the U.S. state of Maryland. The 79.24-mile (127.52 km) route runs from Solomons Island in Calvert County north to an intersection with U.S. Route 1 /US 40 Truck in Baltimore. The route runs concurrent with MD 4 through much of Calvert County along a four-lane divided highway known as Solomons Island Road, passing through rural areas as well as the communities of Lusby, Port Republic, Prince Frederick, and Huntingtown. In Sunderland, MD 2 splits from MD 4 and continues north as two-lane undivided Solomons Island Road into Anne Arundel County, still passing through rural areas. Upon reaching Annapolis, the route runs concurrent with US 50/US 301 to the north of the city. Between Annapolis and Baltimore, MD 2 runs along the Governor Ritchie Highway, a multilane divided highway that heads through suburban areas, passing through Arnold, Severna Park, Pasadena, Glen Burnie, and Brooklyn Park. In Baltimore, the route heads north on city streets and passes through the downtown area of the city.

U.S. Route 50 is a major east–west route of the U.S. Highway system, stretching just over 3,000 miles (4,800 km) from West Sacramento, California, east to Ocean City, Maryland, on the Atlantic Ocean. In the U.S. state of Maryland, US 50 exists in two sections. The longer of these serves as a major route connecting Washington, D.C., with Ocean City; the latter is the eastern terminus of the highway. The other section passes through the southern end of Garrett County for less than 10 miles (16 km) as part of the Northwestern Turnpike, entering West Virginia at both ends. One notable section of US 50 is the dual-span Chesapeake Bay Bridge across the Chesapeake Bay, which links the Baltimore–Washington metropolitan area with the Eastern Shore region, allowing motorists to reach Ocean City and the Delaware Beaches.