Maryland Route 213 (MD 213) is a 68.25-mile (109.84 km) state highway located on the Eastern Shore of Maryland in the United States. The route runs from MD 662 in Wye Mills, Queen Anne's County, north to the Pennsylvania border in Cecil County, where the road continues into that state as Pennsylvania Route 841 (PA 841). The route, which is a two-lane undivided highway most of its length, passes through mainly rural areas as well as the towns of Centreville, Chestertown, Galena, Cecilton, Chesapeake City, and Elkton. MD 213 intersects many routes including U.S. Route 50 (US 50) near Wye Mills, US 301 near Centreville, and US 40 in Elkton. It crosses over the Chesapeake & Delaware Canal in Chesapeake City on the Chesapeake City Bridge. MD 213 is designated by the state as the Chesapeake Country Scenic Byway between the southern terminus and Chesapeake City with the portion north of MD 18 in Centreville a National Scenic Byway. In addition, the route is also considered part of the Atlantic to Appalachians Scenic Byway between Chesapeake City and MD 273 in Fair Hill.

The Eastern Shore of Maryland is a part of the U.S. state of Maryland that lies mostly on the east side of the Chesapeake Bay. Nine counties are normally included in the region. The Eastern Shore is part of the larger Delmarva Peninsula that Maryland shares with Delaware and Virginia.