Maryland Route 222 (MD 222) is a state highway in the U.S. state of Maryland. The highway runs 11.36 miles (18.28 km) from MD 7 in Perryville north to U.S. Route 1 (US 1) near Conowingo. MD 222 connects Perryville, Port Deposit, and Conowingo along its route paralleling the Susquehanna River in western Cecil County. Due to limitations in the highway in Port Deposit, including a steep hill and a low-clearance railroad bridge, trucks are directed to use MD 275, MD 276, and US 1 through Woodlawn and Rising Sun to connect Interstate 95 (I-95) with US 222 in Conowingo.

Maryland Route 7 (MD 7) is a collection of state highways in the U.S. state of Maryland. Known for much of their length as Philadelphia Road, there are five disjoint mainline sections of the highway totaling 40.23 miles (64.74 km) that parallel U.S. Route 40 (US 40) in Baltimore, Harford, and Cecil counties in northeastern Maryland. The longest section of MD 7 begins at US 40 just east of the city of Baltimore in Rosedale and extends through eastern Baltimore County and southern Harford County to US 40 in Aberdeen. The next segment of the state highway is a C-shaped route through Havre de Grace on the west bank of the Susquehanna River. The third mainline section of MD 7 begins in Perryville on the east bank of the Susquehanna River and ends at US 40 a short distance west of the start of the fourth section, which passes through Charlestown and North East before ending at US 40, just west of Elkton. The fifth segment of the highway begins at South Street and passes through the eastern part of Elkton before reconnecting with US 40 east of Elkton and west of the Delaware state line.