Maryland Route 34 is a state highway in the U.S. state of Maryland. Known for most of its length as Shepherdstown Pike, the state highway begins at the West Virginia state line at the Potomac River, where the highway continues south as West Virginia Route 480 through Shepherdstown. The state highway runs 9.95 miles (16.01 km) east to U.S. Route 40 Alternate in Boonsboro. MD 34 is the main east–west highway of southern Washington County, connecting Shepherdstown and Boonsboro with Sharpsburg and Keedysville. The state highway, which was preceded by the Boonsboro and Sharpstown Turnpike, was constructed as a modern highway in the late 1910s and early 1920s. MD 34's bypass of Keedysville opened around 1960. The western end of the state highway has had three bridges. A 19th-century bridge was destroyed in a 1936 flood and replaced by the James Rumsey Bridge in 1939. The present bridge, also named for James Rumsey, opened in 2005.

West Virginia Route 480 is a 5.64-mile-long (9.08 km) state highway in the U.S. state of West Virginia. Known for most of its length as Kearneysville Pike, the highway extends from WV 115 in Kearneysville north to the Maryland state line at the Potomac River in Shepherdstown, from where the highway continues as Maryland Route 34. The route is one of the main north–south highways of northern Jefferson County and passes through the campus of Shepherd University. WV 480 was originally established in the early 1920s as West Virginia Route 48. The highway was paved in the mid-1920s, which included a different routing through Shepherdstown. WV 48's present routing through the town was established in the late 1930s when the first James Rumsey Bridge was completed; that bridge was replaced with the current bridge in the mid-2000s. WV 48 was renumbered to WV 480 in the mid-1970s after U.S. Route 48 was established in West Virginia and Maryland.