Maryland Route 349 is a state highway in the U.S. state of Maryland. Known as Nanticoke Road, the state highway runs 22.32 miles (35.92 km) from a dead end in Nanticoke east to U.S. Route 50 Business in Salisbury. The first segment of MD 349 was constructed by 1910 west of Salisbury. The modern highway reached Quantico by 1919, Bivalve by 1925, and its western terminus by 1933. The only major change to MD 349 since is a realignment near Salisbury in the mid-1950s.

U.S. Route 50 Business is a business route of U.S. Route 50 in the U.S. state of Maryland. The highway runs 6.88 miles (11.07 km) from US 50 on the northwest side of Salisbury to US 13 and US 50 on the east side of Salisbury in central Wicomico County. US 50 Business is a four- to six-lane divided highway within and on either side of the central business district of Salisbury, where the highway intersects MD 349, US 13 Business, and MD 346. US 50 Business west of MD 349 is a mid-1950s upgrade of the original highway entering Salisbury from the northwest. The business route between MD 349 and MD 346 was a relocation of US 50 from Main Street built in the early 1960s. East of MD 346, US 50 Business is part of the relocation of US 50 between Salisbury and Berlin completed in the mid-1960s. US 50 Business was designated when the US 50 portion of the Salisbury Bypass was completed in 2002.