Marylebone Lane is one of the original streets of the Marylebone district of the City of Westminster, London. It runs from Oxford Street in the south to Marylebone High Street in the north, its winding shape following the course of the River Tyburn that it once ran alongside and pre-dating the grid pattern of the other streets in the area. Today the lane is largely composed of small shops, cafes and restaurants with some small apartment blocks. There are some larger commercial buildings at the southern end near Oxford Street.

Marylebone is an area in London, England and is located in the City of Westminster. It is in Central London and part of the West End. Oxford Street forms its southern boundary.