Masaryktown is an unincorporated community and census-designated place (CDP) in Hernando County, Florida, United States. The population was 1,077 at the 2020 census. It is named after the first president of Czechoslovakia, Tomáš Garrigue Masaryk.

Hernando County is a county located on the west central coast of the U.S. state of Florida. As of the 2020 census, the population was 194,515. Its county seat is Brooksville, and its largest community is Spring Hill.