Massachusetts Avenue station is a rapid transit station in the South End and Symphony neighborhoods of Boston, Massachusetts. It serves the MBTA Orange Line, and is located at 380 Massachusetts Avenue. The station opened in 1987 as part of the renovation and relocation of the southern Orange Line into the Southwest Corridor. The Orange line runs parallel to the Northeast Corridor, which carries Amtrak trains and several MBTA commuter rail lines.

The South End is a neighborhood in Boston, Massachusetts, United States which is bordered by Back Bay, Chinatown, and Roxbury. It is distinguished from other neighborhoods by its Victorian-style houses and the parks in and around the area. The South End is the largest intact Victorian row-house district in the country, covering over 300 acres (120 ha). It has eleven residential parks. In 1973, the South End was listed on the National Register of Historic Places. Much of the neighborhood was originally marshlands in Boston's South Bay. After it was filled in, construction began in 1849.