Route 110 is a 69.24-mile-long (111.43 km) southwest–northeast state route in the U.S. state of Massachusetts. Route 110’s western terminus is at a concurrency of Route 12 and Route 140 in West Boylston, and its eastern terminus is at the junction of U.S. 1 and Route 1A in Sailsbury, a few miles from the Atlantic Ocean. Route 110 provides an alternate route for the northern part of I-495.

Route 140 is a 107.76-mile-long (173.42 km) north—south state highway which passes through Bristol, Norfolk and Worcester counties in Massachusetts. The highway follows a southeast-northwest trajectory, running from U.S. Route 6 in New Bedford just north of Buzzards Bay northwest to an intersection with Route 12 in Winchendon, a few miles south of the border with New Hampshire.