Route 112 is a 54.11-mile-long (87.08 km) rural state highway through western Franklin and Hampshire Counties. It begins at U.S. Route 20 in Huntington and ends at the Vermont state line in Colrain, where it continues as Vermont Route 112.

Franklin County is a nongovernmental county located in the northwestern part of the U.S. state of Massachusetts. As of the 2020 census, the population was 71,029, which makes it the least-populous county on the Massachusetts mainland, and the third-least populous county in the state. Its traditional county seat and most populous city is Greenfield. Its largest town by area is New Salem. Franklin County comprises the Greenfield Town, MA Micropolitan Statistical Area, which is included in the Springfield-Greenfield Town, MA Combined Statistical Area.