Route 135 is a 29.53-mile-long (47.52 km) east-west state highway in eastern Massachusetts. The western terminus is at U.S. Route 20 in Northborough and the eastern terminus is at I-95 and Route 128 in Dedham.

Northborough is a town in Worcester County, Massachusetts, United States. The official spelling of the town's name is "Northborough," but the alternative spelling "Northboro" is also used. The population was 15,741 at the 2020 census.