Route 28 is a 151.93-mile-long (244.51 km) nominally south–north state highway in the U.S. state of Massachusetts, running from the town of Eastham via Boston to the New Hampshire state line in Methuen. Following the route from its nominally southern end, Route 28 initially heads south to the town of Chatham then turns west to follow along the south shore of Cape Cod. In Falmouth, Route 28 turns north and continues through the western part of Plymouth County and the eastern part of Norfolk County; it then passes through downtown Boston before heading north via Lawrence to the New Hampshire state line, where it continues as New Hampshire Route 28.

Methuen is a 23-square-mile city in Essex County, Massachusetts, United States. The population was 53,059 at the 2020 census. Methuen lies along the northwestern edge of Essex County, just east of Middlesex County and just south of Rockingham County, New Hampshire. The city is bordered by Haverhill to the northeast, North Andover to the southeast, Lawrence and Andover to the south, Dracut to the west, Pelham, New Hampshire to the northwest, and Salem, New Hampshire to the north. Methuen is located 17 miles (27 km) southwest from Newburyport, 30 miles (48 km) north-northwest of Boston and 25 miles (40 km) south-southeast of Manchester, New Hampshire.