Route 38 is a state highway in the U.S. state of Massachusetts, traveling 26.5 miles (42.6 km) from Route 28 in Somerville north via Lowell to the New Hampshire state line in Dracut, where it continues as New Hampshire Route 38 in Pelham, New Hampshire. Although its southern terminus is at Route 28, some signage indicates that Route 38 continues south towards Sullivan Square in Boston.

Route 28 is a 151.93-mile-long (244.51 km) nominally south–north state highway in the U.S. state of Massachusetts, running from the town of Eastham via Boston to the New Hampshire state line in Methuen. Following the route from its nominally southern end, Route 28 initially heads south to the town of Chatham then turns west to follow along the south shore of Cape Cod. In Falmouth, Route 28 turns north and continues through the western part of Plymouth County and the eastern part of Norfolk County; it then passes through downtown Boston before heading north via Lawrence to the New Hampshire state line, where it continues as New Hampshire Route 28.