Route 38 is a state highway in the U.S. state of Massachusetts, traveling 26.5 miles (42.6 km) from Route 28 in Somerville north via Lowell to the New Hampshire state line in Dracut, where it continues as New Hampshire Route 38 in Pelham, New Hampshire. Although its southern terminus is at Route 28, some signage indicates that Route 38 continues south towards Sullivan Square in Boston.

Route 16 is a 59.8646-mile-long (96.3427 km) east–west state highway in Massachusetts. It begins in the west at an intersection with Route 12 and Route 193 in Webster, just north of the Connecticut state border. It runs in a generally southwest-northeast routing through a number of Boston's suburbs and runs to the west and then north of the city before ending in Revere at an intersection with Route 1A and Route 60.