Route 53 is a 22.138-mile-long (35.628 km) south–north state highway in southeastern Massachusetts. Its southern terminus is at Route 3A in Kingston and its northern terminus is at Route 3A in Quincy. Along the way it intersects Route 3 in Hanover.

Route 3A is a 97-mile-long (156 km) state highway in eastern Massachusetts, which parallels Route 3 and U.S. Route 3 from Cedarville in southern Plymouth to Tyngsborough at the New Hampshire state line.