Massachusetts Senate's 2nd Hampden and Hampshire district in the United States is one of 40 legislative districts of the Massachusetts Senate. It covers 29.3% of Hampden County and 13.8% of Hampshire County population in 2010. Democrat John Velis has represented the district since May 2020.

John Christopher Velis is an American state legislator and Democratic member of the Massachusetts Senate since 2020. He previously represented the 2nd Hampden and Hampshire district, which includes his hometown of Westfield, and currently represents the Hampden and Hampshire district after the 2020 census. Prior his election to the state senate, Velis was a member of the Massachusetts House of Representatives from 2014 to 2020.