Masyaf is a city in northwestern Syria. It is the center of the Masyaf District in the Hama Governorate. As of 2004, Masyaf had a religiously diverse population of approximately 22,000 Ismailis, Alawites and Christians. The city is well known for its large medieval castle, particularly its role as the headquarters of the Nizari Ismailis and their elite Assassins unit.

The Banu Munqidh, also referred to as the Munqidhites, were an Arab family that ruled an emirate in the Orontes Valley in northern Syria from the mid-11th century until the family's demise in an earthquake in 1157. The emirate was initially based in Kafartab before the Banu Munqidh took over the fortress of Shayzar in 1081 and made it their headquarters for the remainder of their rule. The capture of Shayzar was the culmination of a long, drawn-out process beginning with the Banu Munqidh's nominal assignment to the land by the Mirdasid emir of Aleppo in 1025, and accelerating with the weakened grip of Byzantine rule in northern Syria in the 1070s.