Masyaf is a city in northwestern Syria. It is the center of the Masyaf District in the Hama Governorate. As of 2004, Masyaf had a religiously diverse population of approximately 22,000 Ismailis, Alawites and Christians. The city is well known for its large medieval castle, particularly its role as the headquarters of the Nizari Ismailis and their elite Assassins unit.

Hama Governorate is one of the 14 governorates of Syria. It is situated in western-central Syria, bordering Idlib and Aleppo Governorates to the north, Raqqa Governorate to the east, Homs Governorate to the south, and Tartus and Latakia Governorate to the west. It is the only Governorate that does not border a foreign country. Measures of its area vary from 8,844 km2 to 8,883 km2, with its capital being the city of Hama.