The Matane River is a river flowing in La Matanie Regional County Municipality, in administrative region of Bas-Saint-Laurent, on the Gaspé Peninsula, in the province of Quebec, Canada, which empties into the Saint Lawrence River at the city of Matane.

The Bas-Saint-Laurent, is an administrative region of Quebec located along the south shore of the lower Saint Lawrence River in Quebec. The river widens at this place, later becoming a bay that discharges into the Atlantic Ocean and is often nicknamed "Bas-du-Fleuve" (Lower-River). The region is formed by eight regional county municipalities and 114 municipalities. In the south, it borders Maine of the United States, and the Canadian New Brunswick and the regions of Chaudière-Appalaches and Gaspésie–Îles-de-la-Madeleine.