The Matapedia River is a river in the Matapedia Valley in the province of Quebec, Canada. It runs on 65 kilometres (40 mi) from Matapedia Lake down to the village of Matapédia where it empties into the left bank of Restigouche River on the provincial border of New Brunswick.

The Matapedia Valley was formed by the Chic-Choc Mountains of eastern Québec. Its name is derived from the river that traverses the valley, as well as the lake that lies in its center. It is situated in the southwest of the Gaspé Peninsula and stretches 375 km (233 mi).