Matsumoto is a city located in Nagano Prefecture, Japan. Matsumoto is designated as a core city since 1 April 2021. As of 1 March 2019, the city had a population of 239,466 in 105,207 households and a population density of 240 persons per km2. The total area of the city is 978.47 square kilometres (377.79 sq mi).

Matsumoto Domain was a feudal domain under the Tokugawa shogunate of Edo period Japan. It is located in Shinano Province, Honshū. The domain was centered at Matsumoto Castle, located in what is the city of Matsumoto in Nagano Prefecture.