Matsumoto Domain was a feudal domain under the Tokugawa shogunate of Edo period Japan. It is located in Shinano Province, Honshū. The domain was centered at Matsumoto Castle, located in what is the city of Matsumoto in Nagano Prefecture.

Matsumoto Castle , originally known as Fukashi Castle, is one of Japan's premier historic castles, along with Himeji and Kumamoto. It was the seat of Matsumoto Domain under the Edo Period Tokugawa shogunate. It is located in the city of Matsumoto, in Nagano Prefecture.