Matsusaka Castle was a Japanese castle located in the city of Matsusaka, Mie Prefecture, Japan. Throughout most of the Edo period, Matsusaka Castle was a secondary administrative center for the Kishu-Tokugawa clan, daimyō of Kishū Domain. It has been protected as a National Historic Site since 2011.

Japanese castles are fortresses constructed primarily of wood and stone. They evolved from the wooden stockades of earlier centuries and came into their best-known form in the 16th century. Castles in Japan were built to guard important or strategic sites, such as ports, river crossings, or crossroads, and almost always incorporated the landscape into their defenses.