Maupin is a city in Wasco County, Oregon, United States. Located on the Deschutes River, much of the city's economy is related to the river through outdoor activities, such as fishing and rafting. The population was 418 at the 2010 census.

Wasco County is one of the 36 counties in the U.S. state of Oregon. As of the 2020 census, the population was 25,213. Its county seat is The Dalles. The county is named for a local tribe of Native Americans, the Wasco, a Chinook tribe who live on the south side of the Columbia River. It is near the Washington state line. Wasco County comprises The Dalles Micropolitan Statistical Area.