The Mayflower Hotel is a historic hotel in downtown Washington, D.C., located on Connecticut Avenue NW. It is two blocks north of Farragut Square and one block north of the Farragut North Metro station. The hotel is managed by Autograph Collection Hotels, a division of Marriott International.

Warren and Wetmore was an architecture firm based in New York City, a partnership established about 1889 by Whitney Warren (1864–1943) and Charles D. Wetmore (1866–1941). They had one of the most extensive practices of their time, and were especially known for having designed many large hotels.