The Mayo Clinic Alix School of Medicine (MCASOM), formerly known as Mayo Medical School (MMS), is a research-oriented medical school based in Rochester, Minnesota, with additional campuses in Arizona and Florida. MCASOM is a school within the Mayo Clinic College of Medicine and Science (MCCMS), the education division of the Mayo Clinic. It grants the Doctor of Medicine (M.D.) degree, accredited by the Higher Learning Commission (HLC) and the Liaison Committee on Medical Education (LCME). In November 2018, the school was renamed in honor of a $200 million donation from businessman Jay Alix.

Rochester is a city in and the county seat of Olmsted County, Minnesota, United States. Located on rolling bluffs on the Zumbro River's south fork in Southeast Minnesota, the city is the home and birthplace of Mayo Clinic.