The mayor of Tower Hamlets is the directly elected mayor of Tower Hamlets London Borough Council in east London, England. The first election for this position occurred on 21 October 2010, taking on the executive function of the borough council. The position is different from the previous largely ceremonial, annually appointed mayors of Tower Hamlets, who became known as the 'Chair of Council' after the first election and are now known as the 'Speaker of Council'. The second election was held on 22 May 2014, the same day as the Tower Hamlets Council election, other United Kingdom local elections, and European Parliament elections, but the election result was declared void by the election court. A by-election was held on 11 June 2015.

Local authority areas in England typically have an executive leader and a cabinet selected from the local council, similar to how the national prime minister and cabinet are selected from Parliament. In contrast, residents of some areas, or groups of areas known as combined authorities or combined county authorities, directly elect the executive mayors of their local government.