Mbarara City is a city in the Western Region of Uganda and the second largest city in Uganda after Kampala. The city is divided into 6 boroughs of Kakoba Division, Kamukuzi Division, Nyamitanga Division, Biharwe Division, Kakiika Division, Nyakayojo Division. It is the main commercial centre of most of south western districts of Uganda and the site of the district headquarters. In May 2019, the Uganda's cabinet granted Mbarara a city status, which started on 1 July 2020.

The Western Region of Uganda is one of four regions in the country of Uganda. As of Uganda's 2014 census, the Western region's population was 8,874,862.