Me, Myself & Irene is a 2000 American slapstick black comedy film directed by the Farrelly brothers, and starring Jim Carrey and Renée Zellweger. Chris Cooper, Robert Forster, Richard Jenkins, Daniel Greene, Anthony Anderson, Jerod Mixon and Mongo Brownlee co-star. The film is about a Rhode Island state trooper named Charlie who, after years of continuously suppressing his rage and feelings, suffers a psychotic breakdown that results in a second personality, Hank. This was Carrey's first role in a 20th Century Fox film, along with being the Farrelly brothers' second film with Carrey since Dumb and Dumber (1994). Filming was done from May 11 to July 29, 1999 in various locations in Rhode Island and Vermont.

Peter Farrelly and Bobby Farrelly, collectively referred to as the Farrelly brothers, are American screenwriters and directors. They have made eleven films together, including Dumb and Dumber, Outside Providence, and There's Something About Mary.