Medford High School is a public high school located in the western edge of the Lawrence Estates section of Medford, Massachusetts on the southwest border of the Middlesex Fells Reservation. Students in the City of Medford may also attend the Medford Vocational-Technical High School on the same site, or the Curtis/Tufts alternative high school in South Medford.

Medford is a city 6.7 miles (10.8 km) northwest of downtown Boston on the Mystic River in Middlesex County, Massachusetts, United States. At the time of the 2020 U.S. Census, Medford's population was 59,659. It is home to Tufts University, which has its campus on both sides of the Medford and Somerville border.