Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes. It was discovered in 1990 in the lab of Roger D. Kornberg, recipient of the 2006 Nobel Prize in Ch
Figure 1: Diagram of Mediator with its cyclin-dependent kinase module attached
Figure 2: Mediator structural model
Figure 3: Structural model of Mediator's tail and middle bound to RNA polymerase II
Figure 4: Model of Mediator with some transcription factors, Pol II and DNA
RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. It consists of RNA polymerase II, a subset of general
RNA Pol II in action, showing the CTD extension to the C-terminal of POLR2A.