The Medical Arts Building is an office high-rise located at 603 Main Street in Knoxville, Tennessee, United States. Completed in 1931, the 10-story structure originally provided office space for physicians and dentists, and at the time was considered the "best equipped" medical building in the South. The building has been listed on the National Register of Historic Places as one of the region's best examples of a Gothic Revival-style office building. It has recently been renovated into mixed-use, principally residential use.

The South Market Historic District is a cluster of five buildings at the intersection of Market Street and Church Avenue in Knoxville, Tennessee, United States, listed on the National Register of Historic Places in 1996. The buildings, which include the Cherokee Building, the Ely Building, the Cunningham, the Stuart, and the Cate, were built circa 1895—1907, and were used for both office space and residential space. Several prominent Knoxville physicians and three marble companies operated out of the buildings in this district in the early 1900s.